After signing with Republic Records, she released her debut single "Put Your Hearts Up" in December 2011, but it failed to enter any official record chart.
Grande's chart debut was made in April 2013 with "The Way", featuring Mac Miller, which peaked at #9 on the Billboard Hot 100. Her debut studio album Yours Truly reached the top 10 in many countries while debuting at #1 on the US Billboard 200. The album spawned two more singles: "Baby I" and "Right There", the former peaked at #6 in Japan.
Grande released her second studio album My Everything in August 2014. It became her second consecutive #1 record on the Billboard 200. Its lead single, "Problem" was an international hit and nearly reached the top 10 spots of every major chart, including #2 on the Billboard Hot 100 and #1 in the United Kingdom. The subsequent two singles, "Break Free" and "Bang Bang", also achieved international success, and both reached the top 5 in the United States, which made her the second lead female artist to have three top ten singles simultaneously on the Billboard Hot 100. The fourth and fifth singles from the album, "Love Me Harder" and "One Last Time", respectively peaked at #7 and #13 in the United States, also making her the only artist to score four top 10 hits on the Billboard Hot 100 in 2014.
Grande's third studio album, Dangerous Woman, was released in May 2016. It peaked at #2 in the United States while topping the charts in the United Kingdom and other twelve countries. Its eponymous lead single debuted at number ten and peaked at number eight on the Billboard Hot 100, making her the first and only artist in the chart's history to debut in the top ten with the lead single from each of her first three albums. Subsequent two singles, "Into You" and "Side To Side", also achieved commercial success, with both singles entering the top 20 in the United States and the United Kingdom.
Grande's fourth studio album, Sweetener, was released on August 17 2018. it peaked at #1 on Billboard Top 200. The lead single "No Tears Left To Cry", released on April 20, 2018, debuted at #3 on the Billboard Hot 100, extending her record of the only artist to debut in the top ten with the lead single from the first four albums.
In February 2019, Grande released her fifth studio album Thank U, Next. The album produced two Billboard Hot 100 number-one debut singles—"Thank U, Next" and "7 Rings"—becoming Grande's first number-one singles in the United States. With this, Grande joined Mariah Carey and Britney Spears as the only female artists to have two or more singles debuting atop of the Hot 100. Thank U, Next also joined Mariah Carey's Daydream as the only female albums with its two first singles debuting at number one on the Hot 100.