On August 10, 2016, Diplo posted on his Snapchat that he was working with Ariana on a new song. 12 Days later, a fan met Diplo at the airport and asked him what the name of the song they worked on was called and he responded: "In Your Hands". A few days later, Ariana Grande released a small snippet of her and Diplo in the studio together.
On April 26, 2018, a fan tweeted: "i can handle you releasing in your hands or collabing with pabllo again" to which Diplo replied "O baby it's coming".
On September 11, 2018, a short snippet of the song was leaked online.
On October 20, 2018, another short snippet was leaked.