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Stand Up to Cancer (SU2C) is a charitable program of the Entertainment Industry Foundation (EIF). SU2C aims to raise significant funds for translational cancer research through online and televised efforts. Central to the program is a telethon that was first televised by four major broadcast networks (ABC, NBC, CBS, Fox) in over 170 countries on September 5, 2008. SU2C raised over $100 million after that evening's broadcast. Funds collected by Stand Up to Cancer are then distributed by the American Association for Cancer Research.

In 2014, Ariana performed at the show.

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