- Ariana performed "Be Alright" at March For Our Lives on March 24, 2018, in Washington, D.C.
- Grande released "No Tears Left To Cry" on April 20, 2018, as her fourth album's lead single. The song debuted at #3 on the Billboard Hot 100, making Grande the first person in history to have the lead single from each of her first four albums debut in the top 10 ("The Way" #10, "Problem" #3, "Dangerous Woman" #10 and "no tears left to cry" #3)
- On April 21, Ariana made a surprise at Coachella during Kygo's set.
- She performed a remix of Marvin Gaye's "Sexual Healing" and her single "No Tears Left To Cry".
- On May 1, Ariana appeared on The Tonight Show Starring Jimmy Fallon, where she performed "No Tears Left To Cry" and announced her album's title, Sweetener.
- On May 7, she attended the 2018 Met Gala.
- On May 30, Grande confirmed her relationship with Pete Davidson.
- The couple were engaged to be married. However, on October 14, 2018 it was reported that the engagement was called off.
- On July 13, the second single of "Sweetener" was released "God is a woman".
- Debuted at #11 on Billboard Hot 100
- On August 14, Grande appeared on the Late Late Show With James Corden
- On August 15, Ariana's Episode of Carpool Karaoke aired on The Late Late Show With James Corden
- On August 16, Grande appeared again on The Tonight Show Staring Jimmy Fallon and performed a tribute to Aretha Franklin.
- On August 17, Ariana released her fourth studio album
- On August 20, Grande began the promotional concer, "The Sweetener Sessions", which finished on September 9.
- Grande covered "A Natural Woman" live at Aretha Franklin's funeral on August 31, 2018.
- After her performance, Bishop Charles H. Ellis III fondled Ariana's breast while hugging her from the side, while he thanked her at the televised funeral of Franklin. Ellis released an apology following coverage of the incident in the press, saying that it was not his intention and that he had hugged all the performers. In the statement, Ellis also apologized for joking that he thought Ariana Grande's name was a Taco Bell product.
- Grande and Davidson adopted a little pig.
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